Particular compounds current in grapefruit are known to inhibit CYP450 3A4 and should raise the bioavailability of swallowed fentanyl (reportedly up to 75% of the dose) and Grownup:Patches provide fentanyl in doses that range between: twelve-100 mcg/hr. Doses must be independently titrated according to prior utilization of opioids. Opioid-naive